Benzothiazole inhibits the growth of Phytophthora capsici through inducing apoptosis and suppressing stress responses and metabolic detoxification.
Identifieur interne : 000574 ( Main/Exploration ); précédent : 000573; suivant : 000575Benzothiazole inhibits the growth of Phytophthora capsici through inducing apoptosis and suppressing stress responses and metabolic detoxification.
Auteurs : Xinyue Mei [République populaire de Chine] ; Yixiang Liu [République populaire de Chine] ; Huichuan Huang [République populaire de Chine] ; Fei Du [République populaire de Chine] ; Lanlin Huang [République populaire de Chine] ; Jiaqing Wu [République populaire de Chine] ; Yiwen Li [République populaire de Chine] ; Shusheng Zhu [République populaire de Chine] ; Min Yang [République populaire de Chine]Source :
- Pesticide biochemistry and physiology [ 1095-9939 ] ; 2019.
Descripteurs français
- KwdFr :
- Antifongiques (pharmacologie), Apoptose (effets des médicaments et des substances chimiques), Benzothiazoles (pharmacologie), Hyphae (effets des médicaments et des substances chimiques), Hyphae (physiologie), Hyphae (ultrastructure), Inactivation métabolique (MeSH), Microscopie électronique à transmission (MeSH), Phytophthora (effets des médicaments et des substances chimiques), Phytophthora (physiologie), Phytophthora (ultrastructure), Protéines fongiques (génétique), Protéome (MeSH), Stress physiologique (MeSH), Transcriptome (effets des médicaments et des substances chimiques).
- MESH :
- effets des médicaments et des substances chimiques : Apoptose, Hyphae, Phytophthora, Transcriptome.
- génétique : Protéines fongiques.
- pharmacologie : Antifongiques, Benzothiazoles.
- physiologie : Hyphae, Phytophthora.
- ultrastructure : Hyphae, Inactivation métabolique, Microscopie électronique à transmission, Phytophthora, Protéome, Stress physiologique.
English descriptors
- KwdEn :
- Antifungal Agents (pharmacology), Apoptosis (drug effects), Benzothiazoles (pharmacology), Fungal Proteins (genetics), Hyphae (drug effects), Hyphae (physiology), Hyphae (ultrastructure), Inactivation, Metabolic (MeSH), Microscopy, Electron, Transmission (MeSH), Phytophthora (drug effects), Phytophthora (physiology), Phytophthora (ultrastructure), Proteome (MeSH), Stress, Physiological (MeSH), Transcriptome (drug effects).
- MESH :
- chemical , genetics : Fungal Proteins.
- chemical , pharmacology : Antifungal Agents, Benzothiazoles.
- drug effects : Apoptosis, Hyphae, Phytophthora, Transcriptome.
- physiology : Hyphae, Phytophthora.
- ultrastructure : Hyphae, Phytophthora.
- Inactivation, Metabolic, Microscopy, Electron, Transmission, Proteome, Stress, Physiological.
Abstract
Benzothiazole (BZO) is an antimicrobial secondary metabolite volatilized by many plants and microbes. However, the mechanism of BZO against phytopathogens is still unclear. Here, we found that BZO has antimicrobial activity against the oomycete pathogen Phytophthora capsici. Transcriptome and proteome analyses demonstrated that BZO significantly suppressed the expression of genes and proteins involved in morphology, abiotic stress defense and detoxification, but induced the activity of apoptosis. Annexin V-FITC/PI staining confirmed that the process of apoptosis was significantly induced by BZO at concentration of 150 mg L-1. FITC-phalloidin actin-cytoskeleton staining combined with hyphal cell wall staining and hyphal ultrastructure studies further confirmed that BZO disrupted the cell membrane and hyphal morphology through disrupting the cytoskeleton, eventually inhibiting the growth of hyphae. These data demonstrated that BZO has multiple modes of action and may act as potential leading compound for the development of new oomycete fungicides. These results also showed that the combination of transcriptomic and proteomic approaches was a useful method for exploring the novel antifungal mechanisms of natural compounds.
DOI: 10.1016/j.pestbp.2018.12.002
PubMed: 30765059
Affiliations:
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Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201</wicri:regionArea><wicri:noRegion>Kunming 650201</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yiwen" sort="Li, Yiwen" uniqKey="Li Y" first="Yiwen" last="Li">Yiwen Li</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201</wicri:regionArea><wicri:noRegion>Kunming 650201</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Shusheng" sort="Zhu, Shusheng" uniqKey="Zhu S" first="Shusheng" last="Zhu">Shusheng Zhu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China. 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College of Resources and Environment, Yunnan Agricultural University, Kunming, Yunnan Province, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; College of Resources and Environment, Yunnan Agricultural University, Kunming, Yunnan Province</wicri:regionArea><wicri:noRegion>Yunnan Province</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yixiang" sort="Liu, Yixiang" uniqKey="Liu Y" first="Yixiang" last="Liu">Yixiang Liu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201</wicri:regionArea><wicri:noRegion>Kunming 650201</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Huichuan" sort="Huang, Huichuan" uniqKey="Huang H" first="Huichuan" last="Huang">Huichuan Huang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201</wicri:regionArea><wicri:noRegion>Kunming 650201</wicri:noRegion></affiliation></author><author><name sortKey="Du, Fei" sort="Du, Fei" uniqKey="Du F" first="Fei" last="Du">Fei Du</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201</wicri:regionArea><wicri:noRegion>Kunming 650201</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Lanlin" sort="Huang, Lanlin" uniqKey="Huang L" first="Lanlin" last="Huang">Lanlin Huang</name><affiliation wicri:level="1"><nlm:affiliation>College of Resources and Environment, Yunnan Agricultural University, Kunming, Yunnan Province, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Resources and Environment, Yunnan Agricultural University, Kunming, Yunnan Province</wicri:regionArea><wicri:noRegion>Yunnan Province</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jiaqing" sort="Wu, Jiaqing" uniqKey="Wu J" first="Jiaqing" last="Wu">Jiaqing Wu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201</wicri:regionArea><wicri:noRegion>Kunming 650201</wicri:noRegion></affiliation></author><author><name sortKey="Li, Yiwen" sort="Li, Yiwen" uniqKey="Li Y" first="Yiwen" last="Li">Yiwen Li</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201</wicri:regionArea><wicri:noRegion>Kunming 650201</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Shusheng" sort="Zhu, Shusheng" uniqKey="Zhu S" first="Shusheng" last="Zhu">Shusheng Zhu</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China. Electronic address: shushengzhu79@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201</wicri:regionArea><wicri:noRegion>Kunming 650201</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Min" sort="Yang, Min" uniqKey="Yang M" first="Min" last="Yang">Min Yang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China. Electronic address: yangminscnc@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201</wicri:regionArea><wicri:noRegion>Kunming 650201</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pesticide biochemistry and physiology</title><idno type="eISSN">1095-9939</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antifungal Agents (pharmacology)</term><term>Apoptosis (drug effects)</term><term>Benzothiazoles (pharmacology)</term><term>Fungal Proteins (genetics)</term><term>Hyphae (drug effects)</term><term>Hyphae (physiology)</term><term>Hyphae (ultrastructure)</term><term>Inactivation, Metabolic (MeSH)</term><term>Microscopy, Electron, Transmission (MeSH)</term><term>Phytophthora (drug effects)</term><term>Phytophthora (physiology)</term><term>Phytophthora (ultrastructure)</term><term>Proteome (MeSH)</term><term>Stress, Physiological (MeSH)</term><term>Transcriptome (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antifongiques (pharmacologie)</term><term>Apoptose (effets des médicaments et des substances chimiques)</term><term>Benzothiazoles (pharmacologie)</term><term>Hyphae (effets des médicaments et des substances chimiques)</term><term>Hyphae (physiologie)</term><term>Hyphae (ultrastructure)</term><term>Inactivation métabolique (MeSH)</term><term>Microscopie électronique à transmission (MeSH)</term><term>Phytophthora (effets des médicaments et des substances chimiques)</term><term>Phytophthora (physiologie)</term><term>Phytophthora (ultrastructure)</term><term>Protéines fongiques (génétique)</term><term>Protéome (MeSH)</term><term>Stress physiologique (MeSH)</term><term>Transcriptome (effets des médicaments et des substances chimiques)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Fungal Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antifungal Agents</term><term>Benzothiazoles</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Hyphae</term><term>Phytophthora</term><term>Transcriptome</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Apoptose</term><term>Hyphae</term><term>Phytophthora</term><term>Transcriptome</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines fongiques</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antifongiques</term><term>Benzothiazoles</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Hyphae</term><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hyphae</term><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Hyphae</term><term>Phytophthora</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Inactivation, Metabolic</term><term>Microscopy, Electron, Transmission</term><term>Proteome</term><term>Stress, Physiological</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="fr"><term>Hyphae</term><term>Inactivation métabolique</term><term>Microscopie électronique à transmission</term><term>Phytophthora</term><term>Protéome</term><term>Stress physiologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Benzothiazole (BZO) is an antimicrobial secondary metabolite volatilized by many plants and microbes. However, the mechanism of BZO against phytopathogens is still unclear. Here, we found that BZO has antimicrobial activity against the oomycete pathogen Phytophthora capsici. Transcriptome and proteome analyses demonstrated that BZO significantly suppressed the expression of genes and proteins involved in morphology, abiotic stress defense and detoxification, but induced the activity of apoptosis. Annexin V-FITC/PI staining confirmed that the process of apoptosis was significantly induced by BZO at concentration of 150 mg L<sup>-1</sup>. FITC-phalloidin actin-cytoskeleton staining combined with hyphal cell wall staining and hyphal ultrastructure studies further confirmed that BZO disrupted the cell membrane and hyphal morphology through disrupting the cytoskeleton, eventually inhibiting the growth of hyphae. These data demonstrated that BZO has multiple modes of action and may act as potential leading compound for the development of new oomycete fungicides. These results also showed that the combination of transcriptomic and proteomic approaches was a useful method for exploring the novel antifungal mechanisms of natural compounds.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30765059</PMID><DateCompleted><Year>2019</Year><Month>03</Month><Day>05</Day></DateCompleted><DateRevised><Year>2019</Year><Month>03</Month><Day>05</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9939</ISSN><JournalIssue CitedMedium="Internet"><Volume>154</Volume><PubDate><Year>2019</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Pesticide biochemistry and physiology</Title><ISOAbbreviation>Pestic Biochem Physiol</ISOAbbreviation></Journal><ArticleTitle>Benzothiazole inhibits the growth of Phytophthora capsici through inducing apoptosis and suppressing stress responses and metabolic detoxification.</ArticleTitle><Pagination><MedlinePgn>7-16</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0048-3575(18)30424-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.pestbp.2018.12.002</ELocationID><Abstract><AbstractText>Benzothiazole (BZO) is an antimicrobial secondary metabolite volatilized by many plants and microbes. However, the mechanism of BZO against phytopathogens is still unclear. Here, we found that BZO has antimicrobial activity against the oomycete pathogen Phytophthora capsici. Transcriptome and proteome analyses demonstrated that BZO significantly suppressed the expression of genes and proteins involved in morphology, abiotic stress defense and detoxification, but induced the activity of apoptosis. Annexin V-FITC/PI staining confirmed that the process of apoptosis was significantly induced by BZO at concentration of 150 mg L<sup>-1</sup>. FITC-phalloidin actin-cytoskeleton staining combined with hyphal cell wall staining and hyphal ultrastructure studies further confirmed that BZO disrupted the cell membrane and hyphal morphology through disrupting the cytoskeleton, eventually inhibiting the growth of hyphae. These data demonstrated that BZO has multiple modes of action and may act as potential leading compound for the development of new oomycete fungicides. These results also showed that the combination of transcriptomic and proteomic approaches was a useful method for exploring the novel antifungal mechanisms of natural compounds.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mei</LastName><ForeName>Xinyue</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; College of Resources and Environment, Yunnan Agricultural University, Kunming, Yunnan Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yixiang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Huichuan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Fei</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Lanlin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>College of Resources and Environment, Yunnan Agricultural University, Kunming, Yunnan Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Jiaqing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yiwen</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China; Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Shusheng</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming 650201, China. Electronic address: shushengzhu79@126.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Min</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education, Yunnan Agricultural University, Kunming 650201, China. Electronic address: yangminscnc@126.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>12</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pestic Biochem Physiol</MedlineTA><NlmUniqueID>1301573</NlmUniqueID><ISSNLinking>0048-3575</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D052160">Benzothiazoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005656">Fungal Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020543">Proteome</NameOfSubstance></Chemical><Chemical><RegistryNumber>G5BW2593EP</RegistryNumber><NameOfSubstance UI="C005465">benzothiazole</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000935" MajorTopicYN="N">Antifungal Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D052160" MajorTopicYN="N">Benzothiazoles</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005656" MajorTopicYN="N">Fungal Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D025301" MajorTopicYN="N">Hyphae</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008658" MajorTopicYN="N">Inactivation, Metabolic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046529" MajorTopicYN="N">Microscopy, Electron, Transmission</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010838" MajorTopicYN="N">Phytophthora</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020543" MajorTopicYN="N">Proteome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013312" MajorTopicYN="N">Stress, Physiological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059467" MajorTopicYN="N">Transcriptome</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antifungal mechanism</Keyword><Keyword MajorTopicYN="N">Benzothiazole</Keyword><Keyword MajorTopicYN="N">Phytophthora capsici</Keyword><Keyword MajorTopicYN="N">Proteome</Keyword><Keyword MajorTopicYN="N">Transcriptome</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>09</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>10</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>12</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>2</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>2</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>3</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30765059</ArticleId><ArticleId IdType="pii">S0048-3575(18)30424-3</ArticleId><ArticleId IdType="doi">10.1016/j.pestbp.2018.12.002</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Mei, Xinyue" sort="Mei, Xinyue" uniqKey="Mei X" first="Xinyue" last="Mei">Xinyue Mei</name></noRegion><name sortKey="Du, Fei" sort="Du, Fei" uniqKey="Du F" first="Fei" last="Du">Fei Du</name><name sortKey="Huang, Huichuan" sort="Huang, Huichuan" uniqKey="Huang H" first="Huichuan" last="Huang">Huichuan Huang</name><name sortKey="Huang, Lanlin" sort="Huang, Lanlin" uniqKey="Huang L" first="Lanlin" last="Huang">Lanlin Huang</name><name sortKey="Li, Yiwen" sort="Li, Yiwen" uniqKey="Li Y" first="Yiwen" last="Li">Yiwen Li</name><name sortKey="Liu, Yixiang" sort="Liu, Yixiang" uniqKey="Liu Y" first="Yixiang" last="Liu">Yixiang Liu</name><name sortKey="Wu, Jiaqing" sort="Wu, Jiaqing" uniqKey="Wu J" first="Jiaqing" last="Wu">Jiaqing Wu</name><name sortKey="Yang, Min" sort="Yang, Min" uniqKey="Yang M" first="Min" last="Yang">Min Yang</name><name sortKey="Zhu, Shusheng" sort="Zhu, Shusheng" uniqKey="Zhu S" first="Shusheng" last="Zhu">Shusheng Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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